Does quinapril improve coronary vasoconstriction in vasospastic angina?]?

Author(s): Anzai H, Saijo T, Nakajima R, Tezuka N, Takagi T, Tsunoda T, Kobayashi N, Nakamura S, Yamaguchi T Affiliation(s): Department of Cardiology, General Ohta Hospital, Gunma. Publication date & source: 2000-12, J Cardiol. , 36(6):379-86.

Publication type: Clinical Trial; Randomized Controlled Trial OBJECTIVES: Endothelial dysfunction is one of the important mechanisms of coronary spasm. Recently, the angiotensin converting enzyme (ACE) inhibitor quinapril, which has a high affinity for vascular ACE, has improved endothelial dysfunction in coronary artery disease. This study investigated whether quinapril improves coronary vasoconstriction induced by acetylcholine in vasospastic angina.

METHODS: Twenty-four patients with vasospastic angina without significant organic stenosis diagnosed by the acetylcholine provocation test (vessel with spasm defined as > or = 90% stenosis provoked with chest pain and/or ischemic ST change) were enrolled in this study. Patients were randomly ... more.

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